Treatment with HIV medicines
is called antiretroviral therapy (ART). ART is recommended for everyone
with HIV. People on ART take a combination of HIV medicines (called an
HIV regimen) every day. A person's initial HIV regimen generally
includes three HIV medicines from at least two different drug classes.
ART can’t cure HIV, but HIV medicines help people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
The following table lists HIV medicines approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the United States. The HIV medicines are listed according to drug class and identified by generic and brand names. Click on a drug name to view information on the drug from the AIDSinfo Drug Database. Or download the AIDSinfo Drug Database app to view the information on your Apple or Android devices.
ART can’t cure HIV, but HIV medicines help people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
The following table lists HIV medicines approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the United States. The HIV medicines are listed according to drug class and identified by generic and brand names. Click on a drug name to view information on the drug from the AIDSinfo Drug Database. Or download the AIDSinfo Drug Database app to view the information on your Apple or Android devices.
| Drug Class | Generic Name (Other names and acronyms) |
Brand Name | FDA Approval Date |
|---|---|---|---|
| Nucleoside Reverse Transcriptase Inhibitors (NRTIs) |
|||
| NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself. | abacavir (abacavir sulfate, ABC) |
Ziagen | December 17, 1998 |
| didanosine (delayed-release didanosine, dideoxyinosine, enteric-coated didanosine, ddI, ddI EC) |
Videx | October 9, 1991 |
|
| Videx EC (enteric-coated) |
October 31, 2000 |
||
| emtricitabine (FTC) |
Emtriva | July 2, 2003 |
|
| lamivudine (3TC) |
Epivir | November 17, 1995 |
|
| stavudine (d4T) |
Zerit | June 24, 1994 |
|
| tenofovir disoproxil fumarate (tenofovir DF, TDF) |
Viread | October 26, 2001 |
|
| zidovudine (azidothymidine, AZT, ZDV) |
Retrovir | March 19, 1987 |
|
| Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) |
|||
| NNRTIs bind to and later alter reverse transcriptase, an enzyme HIV needs to make copies of itself. |
delavirdine (delavirdine mesylate, DLV) |
Rescriptor |
April 4, 1997 |
| efavirenz (EFV) |
Sustiva | September 17, 1998 |
|
| etravirine (ETR) |
Intelence |
January 18, 2008 |
|
| nevirapine (extended-release nevirapine, NVP) |
Viramune |
June 21, 1996 |
|
| Viramune XR (extended release) |
March 25, 2011 |
||
| rilpivirine (rilpivirine hydrochloride, RPV) |
Edurant | May 20, 2011 |
|
| Protease Inhibitors (PIs) |
|||
| PIs block HIV protease, an enzyme HIV needs to make copies of itself |
atazanavir (atazanavir sulfate, ATV) |
Reyataz | June 20, 2003 |
| darunavir (darunavir ethanolate, DRV) |
Prezista | June 23, 2006 |
|
| fosamprenavir (fosamprenavir calcium, FOS-APV, FPV) |
Lexiva | October 20, 2003 |
|
| indinavir (indinavir sulfate, IDV) |
Crixivan |
March 13, 1996 |
|
| nelfinavir (nelfinavir mesylate, NFV) |
Viracept |
March 14, 1997 |
|
| ritonavir (RTV) |
Norvir |
March 1, 1996 |
|
| saquinavir (saquinavir mesylate, SQV) |
Invirase |
December 6, 1995 |
|
| tipranavir (TPV) |
Aptivus |
June 22, 2005 |
|
| Fusion Inhibitors |
|||
| Fusion inhibitors block HIV from entering the CD4 cells of the immune system. |
enfuvirtide (T-20) |
Fuzeon |
March 13, 2003 |
| Entry Inhibitors |
|||
| Entry inhibitors block proteins on the CD4 cells that HIV needs to enter the cells. |
maraviroc (MVC) |
Selzentry |
August 6, 2007 |
| Integrase Inhibitors |
|||
| Integrase inhibitors block HIV integrase, an enzyme HIV needs to make copies of itself. |
dolutegravir (DTG) |
Tivicay |
August 13, 2013 |
| elvitegravir (EVG) |
Vitekta | September 24, 2014 | |
| raltegravir (raltegravir potassium, RAL) |
Isentress |
October 12, 2007 |
|
| Pharmacokinetic Enhancers | |||
| Pharmacokinetic enhancers are used in HIV treatment to increase the effectiveness of an HIV medicine included in an HIV regimen. |
cobicistat (COBI) |
Tybost |
September 24, 2014 |
| Combination HIV Medicines |
|||
| Combination HIV medicines contain two or more HIV medicines from one or more drug classes. |
abacavir and lamivudine (abacavir sulfate / lamivudine, ABC / 3TC) |
Epzicom |
August 2, 2004 |
| abacavir, dolutegravir, and lamivudine (abacavir sulfate / dolutegravir sodium / lamivudine, ABC / DTG / 3TC) |
Triumeq | August 22, 2014 |
|
| abacavir, lamivudine, and zidovudine (abacavir sulfate / lamivudine / zidovudine, ABC / 3TC / ZDV) |
Trizivir |
November 14, 2000 |
|
| atazanavir and cobicistat (atazanavir sulfate / cobicistat, ATV / COBI) |
Evotaz |
January 29, 2015 |
|
| darunavir and cobicistat (darunavir ethanolate / cobicistat, DRV / COBI) |
Prezcobix |
January 29, 2015 |
|
| efavirenz, emtricitabine, and tenofovir disoproxil fumarate (efavirenz / emtricitabine / tenofovir, efavirenz / emtricitabine / tenofovir DF, EFV / FTC / TDF) |
Atripla | July 12, 2006 | |
| elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (QUAD, EVG / COBI / FTC / TDF) |
Stribild | August 27, 2012 | |
| emtricitabine, rilpivirine, and tenofovir disoproxil fumarate (emtricitabine / rilpivirine hydrochloride / tenofovir disoproxil fumarate, emtricitabine / rilpivirine / tenofovir, FTC / RPV / TDF) |
Complera | August 10, 2011 | |
| emtricitabine and tenofovir disoproxil fumarate (emtricitabine / tenofovir, FTC / TDF) |
Truvada | August 2, 2004 | |
| lamivudine and zidovudine (3TC / ZDV) |
Combivir | September 27, 1997 | |
| lopinavir and ritonavir (ritonavir-boosted lopinavir, LPV/r, LPV / RTV) |
Kaletra | September 15, 2000 | |
This fact sheet is based on information from the following sources:
- From FDA: Antiretroviral Drugs Used in the Treatment of HIV Infection
- From the National Institute of Allergy and Infectious Diseases: Drugs That Fight HIV-1
- From the National Library of Medicine: Drug information from the DailyMed website
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